Interações medicamentosas
Metformin + Vitamin B12
Gravidade: Moderada
Metformin and Vitamin B12: moderate interaction.
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Resumo
Long-term metformin therapy is associated with lower serum vitamin B12 levels and occasionally clinical deficiency, including anemia or neuropathy. The risk rises with higher doses, longer duration and other risk factors such as older age or poor intake.
O que esta interação significa em palavras simples
Metformin and Vitamin B12 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin belongs to Endocrine; Vitamin B12 belongs to Gastrointestinal Tract.
Por que acontece
Metformin is thought to impair calcium-dependent ileal absorption of the B12-intrinsic factor complex, though the mechanism is not fully established.
O que fazer
Measure vitamin B12 periodically in patients on long-term metformin, especially those with anemia or neuropathy. Replace B12 if deficient; metformin can usually be continued.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Vitamin B12
Outras interações de Metformin
Perguntas frequentes
Can I take Metformin with Vitamin B12?
MediHelp rates the interaction as moderate. Metformin and Vitamin B12 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Long-term metformin therapy is associated with lower serum vitamin B12 levels and occasionally clinical deficiency, including anemia or neuropathy. The risk rises with higher doses, longer duration and other risk factors such as older age or poor intake.
How serious is the interaction between Metformin and Vitamin B12?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure vitamin B12 periodically in patients on long-term metformin, especially those with anemia or neuropathy. Replace B12 if deficient; metformin can usually be continued.
What other medicines interact with Vitamin B12?
MediHelp also lists interactions of Vitamin B12 with, for example, Chloramphenicol, Dichlorphenamide, Neomycin po. The full list is on the Vitamin B12 page.
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