Interações medicamentosas
Dichlorphenamide + Vitamin B12
Gravidade: Moderada
Dichlorphenamide and Vitamin B12: moderate interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Dichlorphenamide commonly causes potassium loss through its carbonic anhydrase inhibition. Cyanocobalamin can lower potassium when treating severe megaloblastic anemia because of rapid cell production, so low potassium is possible when both are used. This is mainly relevant at initiation of B12 therapy in severely deficient patients.
O que esta interação significa em palavras simples
Dichlorphenamide and Vitamin B12 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Vitamin B12 belongs to Gastrointestinal Tract.
Por que acontece
Additive hypokalemia: renal potassium wasting from carbonic anhydrase inhibition plus increased cellular potassium uptake during hematopoietic recovery after B12 replacement.
O que fazer
Check serum potassium before and during early B12 repletion in patients on dichlorphenamide. Replace potassium as needed.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Vitamin B12
Outras interações de Dichlorphenamide
Perguntas frequentes
Can I take Dichlorphenamide with Vitamin B12?
MediHelp rates the interaction as moderate. Dichlorphenamide and Vitamin B12 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide commonly causes potassium loss through its carbonic anhydrase inhibition. Cyanocobalamin can lower potassium when treating severe megaloblastic anemia because of rapid cell production, so low potassium is possible when both are used. This is mainly relevant at initiation of B12 therapy in severely deficient patients.
How serious is the interaction between Dichlorphenamide and Vitamin B12?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium before and during early B12 repletion in patients on dichlorphenamide. Replace potassium as needed.
What other medicines interact with Vitamin B12?
MediHelp also lists interactions of Vitamin B12 with, for example, Chloramphenicol, Metformin, Neomycin po. The full list is on the Vitamin B12 page.
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