Interações medicamentosas
Methyldopa + Pretomanid
Gravidade: Grave
Methyldopa and Pretomanid: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Pretomanid-containing regimens are associated with hepatotoxicity, and methyldopa can also cause liver injury. Concurrent use may increase the risk of clinically significant hepatic damage.
O que esta interação significa em palavras simples
Methyldopa and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Methyldopa belongs to Cardiovascular; Pretomanid belongs to Anti Bacterial.
Por que acontece
Additive hepatotoxicity from two drugs that can independently injure the liver.
O que fazer
Avoid methyldopa during pretomanid therapy and use an alternative antihypertensive. If unavoidable, monitor liver function tests frequently.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Methyldopa e Pretomanid, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outras interações de Methyldopa
- Methyldopa + Tranylcypromine Contraindicada
- Iobenguane i + Methyldopa Grave
- Lofexidine + Methyldopa Grave
- Methyldopa + Pexidartinib Grave
- Methyldopa + Thioridazine Grave
- Adrenaline-articaine + Methyldopa Moderada
Outras interações de Pretomanid
Perguntas frequentes
Can I take Methyldopa with Pretomanid?
MediHelp rates the interaction as major. Methyldopa and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pretomanid-containing regimens are associated with hepatotoxicity, and methyldopa can also cause liver injury. Concurrent use may increase the risk of clinically significant hepatic damage.
How serious is the interaction between Methyldopa and Pretomanid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid methyldopa during pretomanid therapy and use an alternative antihypertensive. If unavoidable, monitor liver function tests frequently.
What other medicines interact with Methyldopa?
MediHelp also lists interactions of Methyldopa with, for example, Tranylcypromine, Iobenguane i, Lofexidine. The full list is on the Methyldopa page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
