Interações medicamentosas
Amoxicillin-clavulanic acid + Pretomanid
Gravidade: Grave
Amoxicillin-clavulanic acid and Pretomanid: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
The pretomanid-containing regimen is associated with hepatotoxicity, and labeling advises avoiding other hepatotoxic agents. Amoxicillin-clavulanate can cause cholestatic or mixed liver injury. Concurrent use could raise the risk of serious hepatic injury.
O que esta interação significa em palavras simples
Amoxicillin-clavulanic acid and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amoxicillin-clavulanic acid belongs to Anti Bacterial; Pretomanid belongs to Anti Bacterial.
Por que acontece
Additive hepatotoxicity from pretomanid-based therapy and clavulanate-associated liver injury.
O que fazer
Avoid amoxicillin-clavulanate during pretomanid therapy and select a less hepatotoxic antibiotic. If it cannot be avoided, monitor liver function tests frequently.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Amoxicillin-clavulanic acid
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- Amoxicillin-clavulanic acid + Pexidartinib Grave
- Allopurinol + Amoxicillin-clavulanic acid Moderada
- Amoxicillin-clavulanic acid + Bcg vaccine live Moderada
- Amoxicillin-clavulanic acid + Chloramphenicol Moderada
- Amoxicillin-clavulanic acid + Cholera vaccine Moderada
Outras interações de Pretomanid
- Amiodarone + Pretomanid Grave
- Amobarbital + Pretomanid Grave
- Apalutamide + Pretomanid Grave
- Armodafinil + Pretomanid Grave
- Azathioprine + Pretomanid Grave
- Bosentan + Pretomanid Grave
Perguntas frequentes
Can I take Amoxicillin-clavulanic acid with Pretomanid?
MediHelp rates the interaction as major. Amoxicillin-clavulanic acid and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The pretomanid-containing regimen is associated with hepatotoxicity, and labeling advises avoiding other hepatotoxic agents. Amoxicillin-clavulanate can cause cholestatic or mixed liver injury. Concurrent use could raise the risk of serious hepatic injury.
How serious is the interaction between Amoxicillin-clavulanic acid and Pretomanid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid amoxicillin-clavulanate during pretomanid therapy and select a less hepatotoxic antibiotic. If it cannot be avoided, monitor liver function tests frequently.
What other medicines interact with Amoxicillin-clavulanic acid?
MediHelp also lists interactions of Amoxicillin-clavulanic acid with, for example, Methotrexate, Pexidartinib, Allopurinol. The full list is on the Amoxicillin-clavulanic acid page.
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