Interações medicamentosas
Methylprednisolone + Mifepristone
Gravidade: Contraindicada
Methylprednisolone and Mifepristone: contraindicated interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Mifepristone is a glucocorticoid receptor antagonist and can blunt the effect of corticosteroids. In patients on long-term corticosteroids it may cause adrenal insufficiency or loss of disease control, and labeling lists chronic corticosteroid therapy as a contraindication.
O que esta interação significa em palavras simples
Methylprednisolone and Mifepristone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Methylprednisolone belongs to Endocrine; Mifepristone belongs to Endocrine.
Por que acontece
Mifepristone blocks glucocorticoid receptors, opposing the effect of methylprednisolone.
O que fazer
Do not use mifepristone in patients on long-term corticosteroid therapy. Seek specialist advice if both are required, as usual steroid doses may be ineffective.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicada
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicada
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicada
- Measles vaccine + Methylprednisolone Contraindicada
- Methylprednisolone + Rubella vaccine Contraindicada
- Methylprednisolone + Smallpox vaccine live Contraindicada
Outras interações de Mifepristone
- Apixaban + Mifepristone Contraindicada
- Argatroban + Mifepristone Contraindicada
- Cisapride + Mifepristone Contraindicada
- Cortisone + Mifepristone Contraindicada
- Cyclosporin + Mifepristone Contraindicada
- Dabigatran etexilate + Mifepristone Contraindicada
Perguntas frequentes
Can I take Methylprednisolone with Mifepristone?
MediHelp rates the interaction as contraindicated. Methylprednisolone and Mifepristone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Mifepristone is a glucocorticoid receptor antagonist and can blunt the effect of corticosteroids. In patients on long-term corticosteroids it may cause adrenal insufficiency or loss of disease control, and labeling lists chronic corticosteroid therapy as a contraindication.
How serious is the interaction between Methylprednisolone and Mifepristone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use mifepristone in patients on long-term corticosteroid therapy. Seek specialist advice if both are required, as usual steroid doses may be ineffective.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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