Interações medicamentosas
Mosapride + Prucalopride
Gravidade: Moderada
Mosapride and Prucalopride: moderate interaction.
Última atualização Fontes: US FDA label
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Both drugs are 5-HT4 receptor agonists, so using them together duplicates therapy and may increase diarrhea, abdominal cramps, nausea, and headache. This could cause dehydration and electrolyte loss, especially in older or renally impaired patients. There is no good evidence that the combination improves efficacy.
O que esta interação significa em palavras simples
Mosapride and Prucalopride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mosapride belongs to Gastrointestinal Tract; Prucalopride belongs to Gastrointestinal Tract.
Por que acontece
Pharmacodynamic: additive 5-HT4 receptor agonism enhances acetylcholine release in the enteric nervous system and accelerates gastrointestinal transit. No important pharmacokinetic interaction is expected.
O que fazer
Avoid using both and choose a single prokinetic. If switching, stop one agent before starting the other.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Referências
- Motegrity (prucalopride) Prescribing Information — FDA Label
- Resolor (prucalopride) Summary of Product Characteristics — EMA SmPC
Outras interações de Mosapride
- Linaclotide + Mosapride Moderada
- Lubiprostone + Mosapride Moderada
Perguntas frequentes
Can I take Mosapride with Prucalopride?
MediHelp rates the interaction as moderate. Mosapride and Prucalopride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are 5-HT4 receptor agonists, so using them together duplicates therapy and may increase diarrhea, abdominal cramps, nausea, and headache. This could cause dehydration and electrolyte loss, especially in older or renally impaired patients. There is no good evidence that the combination improves efficacy.
How serious is the interaction between Mosapride and Prucalopride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using both and choose a single prokinetic. If switching, stop one agent before starting the other.
What other medicines interact with Mosapride?
MediHelp also lists interactions of Mosapride with, for example, Linaclotide, Lubiprostone. The full list is on the Mosapride page.
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