Interações medicamentosas
Panobinostat + Pimozide
Gravidade: Contraindicada
Panobinostat and Pimozide: contraindicated interaction.
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Resumo
Both drugs prolong the QT interval, so combining them raises the risk of torsades de pointes and other serious arrhythmias. Panobinostat labeling advises against use with QT-prolonging drugs.
O que esta interação significa em palavras simples
Panobinostat and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Panobinostat belongs to Oncology; Pimozide belongs to Central Nervous System.
Por que acontece
Additive prolongation of cardiac repolarization (QT interval).
O que fazer
Do not use together; choose an alternative to pimozide during panobinostat therapy. Keep potassium and magnesium within normal range and monitor ECG if any QT-prolonging drug is required.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Pimozide
- Adagrasib + Pimozide Contraindicada
- Amiodarone + Pimozide Contraindicada
- Amisulpride + Pimozide Contraindicada
- Amitriptyline + Pimozide Contraindicada
- Amoxapine + Pimozide Contraindicada
- Anagrelide + Pimozide Contraindicada
Outras interações de Panobinostat
- Amiodarone + Panobinostat Contraindicada
- Anagrelide + Panobinostat Contraindicada
- Chloroquine + Panobinostat Contraindicada
- Chlorpromazine + Panobinostat Contraindicada
- Dronedarone + Panobinostat Contraindicada
- Haloperidol + Panobinostat Contraindicada
Perguntas frequentes
Can I take Panobinostat with Pimozide?
MediHelp rates the interaction as contraindicated. Panobinostat and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, so combining them raises the risk of torsades de pointes and other serious arrhythmias. Panobinostat labeling advises against use with QT-prolonging drugs.
How serious is the interaction between Panobinostat and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose an alternative to pimozide during panobinostat therapy. Keep potassium and magnesium within normal range and monitor ECG if any QT-prolonging drug is required.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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