Interações medicamentosas
Tretinoin + Urea
Gravidade: Leve
Tretinoin and Urea: minor interaction.
Última atualização Fontes: US FDA label
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Concurrent topical use may increase irritation, dryness and peeling at the application site. Urea may increase skin penetration of tretinoin through its effects on the stratum corneum. The effect is usually mild and local, but sensitive or compromised skin is at greater risk.
O que esta interação significa em palavras simples
Tretinoin and Urea have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Tretinoin belongs to Dermatology; Urea belongs to Miscellaneous.
Por que acontece
Additive local irritation from the retinoid and keratolytic urea, with possible increased tretinoin penetration through a disrupted stratum corneum.
O que fazer
Apply at separate times, for example urea in the morning and tretinoin at night, and avoid high-strength urea on the same area at first. Start with low frequency and monitor for irritation.
O que perguntar ao farmacêutico
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Referências
- Retin-A (tretinoin) Prescribing Information — FDA Label
Outras interações de Tretinoin
- Doxycycline + Tretinoin Grave
- Minocycline + Tretinoin Grave
- Omadacycline + Tretinoin Grave
- Palovarotene + Tretinoin Grave
- Sarecycline + Tretinoin Grave
- Tetracycline + Tretinoin Grave
Outras interações de Urea
- Azelaic acid + Urea Leve
Perguntas frequentes
Can I take Tretinoin with Urea?
MediHelp rates the interaction as minor. Tretinoin and Urea have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Concurrent topical use may increase irritation, dryness and peeling at the application site. Urea may increase skin penetration of tretinoin through its effects on the stratum corneum. The effect is usually mild and local, but sensitive or compromised skin is at greater risk.
How serious is the interaction between Tretinoin and Urea?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Apply at separate times, for example urea in the morning and tretinoin at night, and avoid high-strength urea on the same area at first. Start with low frequency and monitor for irritation.
What other medicines interact with Tretinoin?
MediHelp also lists interactions of Tretinoin with, for example, Doxycycline, Minocycline, Omadacycline. The full list is on the Tretinoin page.
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