Лекарственные взаимодействия
Bcg vaccine live + Methylprednisolone
Тяжесть: Противопоказано
Bcg vaccine live and Methylprednisolone: contraindicated interaction.
Последнее обновление Источники: US FDA label
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Кратко
BCG is a live attenuated vaccine, and immunosuppressive doses of methylprednisolone can allow uncontrolled replication, causing disseminated BCG infection. The vaccine response may also be diminished.
Что означает это взаимодействие простыми словами
Bcg vaccine live and Methylprednisolone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Почему это происходит
Corticosteroid-induced impairment of cell-mediated immunity reduces control of live attenuated organisms.
Что делать
Do not give BCG to patients on immunosuppressive corticosteroid doses. Delay vaccination until the steroid has been stopped for the interval recommended in local guidance, typically at least one month.
О чём спросить фармацевта
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Источники
Другие взаимодействия Methylprednisolone
- Measles mumps and rubella vaccine live + Methylprednisolone Противопоказано
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Противопоказано
- Measles vaccine + Methylprednisolone Противопоказано
- Methylprednisolone + Mifepristone Противопоказано
- Methylprednisolone + Rubella vaccine Противопоказано
- Methylprednisolone + Smallpox vaccine live Противопоказано
Частые вопросы
Can I take Bcg vaccine live with Methylprednisolone?
MediHelp rates the interaction as contraindicated. Bcg vaccine live and Methylprednisolone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. BCG is a live attenuated vaccine, and immunosuppressive doses of methylprednisolone can allow uncontrolled replication, causing disseminated BCG infection. The vaccine response may also be diminished.
How serious is the interaction between Bcg vaccine live and Methylprednisolone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give BCG to patients on immunosuppressive corticosteroid doses. Delay vaccination until the steroid has been stopped for the interval recommended in local guidance, typically at least one month.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live, Measles vaccine. The full list is on the Methylprednisolone page.
Полные монографии, дозировки и проверка взаимодействий в приложении MediHelp
Откройте полный справочник, проверяйте взаимодействия нескольких препаратов и пользуйтесь инструментами дозирования в приложении MediHelp.
