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Лекарственные взаимодействия

Cannabidiol + Flutamide

Тяжесть: Умеренное

Cannabidiol and Flutamide: moderate interaction.

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Кратко

Cannabidiol can both inhibit and induce CYP1A2 in vitro, and flutamide is activated to its hydroxy metabolite mainly through CYP1A2. The net effect on flutamide exposure and on its hepatotoxic metabolites is unpredictable. Both agents can independently raise liver enzymes.

Что означает это взаимодействие простыми словами

Cannabidiol and Flutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Cannabidiol belongs to Central Nervous System; Flutamide belongs to Endocrine.

Уровень доказательности: Low

Почему это происходит

Cannabidiol has mixed inhibitory and inducing effects on CYP1A2, altering flutamide metabolism in an unpredictable direction.

Что делать

Monitor liver function tests regularly, as both drugs can cause hepatotoxicity. Watch for changes in antiandrogen efficacy and adjust therapy accordingly.

О чём спросить фармацевта

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Частые вопросы

Can I take Cannabidiol with Flutamide?

MediHelp rates the interaction as moderate. Cannabidiol and Flutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol can both inhibit and induce CYP1A2 in vitro, and flutamide is activated to its hydroxy metabolite mainly through CYP1A2. The net effect on flutamide exposure and on its hepatotoxic metabolites is unpredictable. Both agents can independently raise liver enzymes.

How serious is the interaction between Cannabidiol and Flutamide?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests regularly, as both drugs can cause hepatotoxicity. Watch for changes in antiandrogen efficacy and adjust therapy accordingly.

What other medicines interact with Flutamide?

MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Levoketoconazole, Pexidartinib. The full list is on the Flutamide page.

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