Drug interactions
Cannabidiol + Flutamide
Severity: Moderate
Cannabidiol and Flutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol can both inhibit and induce CYP1A2 in vitro, and flutamide is activated to its hydroxy metabolite mainly through CYP1A2. The net effect on flutamide exposure and on its hepatotoxic metabolites is unpredictable. Both agents can independently raise liver enzymes.
What this interaction means in plain words
Cannabidiol and Flutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Flutamide belongs to Endocrine.
Why it happens
Cannabidiol has mixed inhibitory and inducing effects on CYP1A2, altering flutamide metabolism in an unpredictable direction.
What to do
Monitor liver function tests regularly, as both drugs can cause hepatotoxicity. Watch for changes in antiandrogen efficacy and adjust therapy accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flutamide
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Flutamide?
MediHelp rates the interaction as moderate. Cannabidiol and Flutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol can both inhibit and induce CYP1A2 in vitro, and flutamide is activated to its hydroxy metabolite mainly through CYP1A2. The net effect on flutamide exposure and on its hepatotoxic metabolites is unpredictable. Both agents can independently raise liver enzymes.
How serious is the interaction between Cannabidiol and Flutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests regularly, as both drugs can cause hepatotoxicity. Watch for changes in antiandrogen efficacy and adjust therapy accordingly.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Levoketoconazole, Pexidartinib. The full list is on the Flutamide page.
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