Лекарственные взаимодействия
Ceftriaxone + Lactated Ringer's solution
Тяжесть: Тяжёлое
Ceftriaxone and Lactated Ringer's solution: major interaction.
Последнее обновление Источники: US FDA label
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Кратко
Ceftriaxone can form insoluble calcium-ceftriaxone precipitates when mixed with calcium-containing solutions such as lactated Ringer's. Fatal cases of lung and kidney deposits have occurred in neonates. Labeling contraindicates concomitant use in neonates and prohibits mixing in the same line for all patients.
Что означает это взаимодействие простыми словами
Ceftriaxone and Lactated Ringer's solution can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Почему это происходит
Physicochemical incompatibility: ceftriaxone binds calcium to form insoluble calcium salts that precipitate in lines or in vivo.
Что делать
Do not reconstitute or dilute ceftriaxone with lactated Ringer's or any calcium-containing solution, and do not give through the same line simultaneously. In patients older than 28 days, sequential administration is acceptable only if the line is thoroughly flushed with a compatible fluid between infusions.
О чём спросить фармацевта
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Источники
- Ceftriaxone for Injection Prescribing Information - Contraindications and Warnings — FDA Label
- Rocephin Summary of Product Characteristics — EMA SmPC
Другие взаимодействия Ceftriaxone
- Calcium chloride + Ceftriaxone Противопоказано
- Calcium gluconate + Ceftriaxone Противопоказано
- Calcium + Ceftriaxone Противопоказано
- Ceftriaxone + Lactated ringer's Противопоказано
- Ceftriaxone + Ringer's solution Противопоказано
- Calcium acetate + Ceftriaxone Тяжёлое
Частые вопросы
Can I take Ceftriaxone with Lactated Ringer's solution?
MediHelp rates the interaction as major. Ceftriaxone and Lactated Ringer's solution can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ceftriaxone can form insoluble calcium-ceftriaxone precipitates when mixed with calcium-containing solutions such as lactated Ringer's. Fatal cases of lung and kidney deposits have occurred in neonates. Labeling contraindicates concomitant use in neonates and prohibits mixing in the same line for all patients.
How serious is the interaction between Ceftriaxone and Lactated Ringer's solution?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not reconstitute or dilute ceftriaxone with lactated Ringer's or any calcium-containing solution, and do not give through the same line simultaneously. In patients older than 28 days, sequential administration is acceptable only if the line is thoroughly flushed with a compatible fluid between infusions.
What other medicines interact with Ceftriaxone?
MediHelp also lists interactions of Ceftriaxone with, for example, Calcium chloride, Calcium gluconate, Calcium. The full list is on the Ceftriaxone page.
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