Лекарственные взаимодействия
Ceftriaxone + Ringer's solution
Тяжесть: Противопоказано
Ceftriaxone and Ringer's solution: contraindicated interaction.
Последнее обновление Источники: US FDA label
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Кратко
Ceftriaxone can form an insoluble ceftriaxone-calcium precipitate when mixed with calcium-containing solutions such as Ringer's or lactated Ringer's. Fatal cases of crystalline deposits in the lungs and kidneys have occurred in neonates given ceftriaxone and calcium-containing intravenous fluids. In neonates the combination is contraindicated, and in older patients it must not be mixed or co-infused in the same line.
Что означает это взаимодействие простыми словами
Ceftriaxone and Ringer's solution are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Почему это происходит
Ceftriaxone binds calcium to form poorly soluble ceftriaxone-calcium salt, which precipitates in IV lines and in vivo.
Что делать
Do not give ceftriaxone to neonates (up to 28 days) who need or are expected to need calcium-containing IV solutions, including Ringer's.
О чём спросить фармацевта
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Источники
- Rocephin (ceftriaxone) Prescribing Information - Contraindications and Warnings: Interaction with calcium-containing products — FDA Label
- Ceftriaxone Summary of Product Characteristics - Contraindications and Interactions with calcium — EMA SmPC
Другие взаимодействия Ceftriaxone
- Calcium chloride + Ceftriaxone Противопоказано
- Calcium gluconate + Ceftriaxone Противопоказано
- Calcium + Ceftriaxone Противопоказано
- Ceftriaxone + Lactated ringer's Противопоказано
- Calcium acetate + Ceftriaxone Тяжёлое
- Ceftriaxone + Lactated Ringer's solution Тяжёлое
Частые вопросы
Can I take Ceftriaxone with Ringer's solution?
MediHelp rates the interaction as contraindicated. Ceftriaxone and Ringer's solution are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ceftriaxone can form an insoluble ceftriaxone-calcium precipitate when mixed with calcium-containing solutions such as Ringer's or lactated Ringer's. Fatal cases of crystalline deposits in the lungs and kidneys have occurred in neonates given ceftriaxone and calcium-containing intravenous fluids. In neonates the combination is contraindicated, and in older patients it must not be mixed or co-infused in the same line.
How serious is the interaction between Ceftriaxone and Ringer's solution?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give ceftriaxone to neonates (up to 28 days) who need or are expected to need calcium-containing IV solutions, including Ringer's.
What other medicines interact with Ceftriaxone?
MediHelp also lists interactions of Ceftriaxone with, for example, Calcium chloride, Calcium gluconate, Calcium. The full list is on the Ceftriaxone page.
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