Лекарственные взаимодействия
Ceftriaxone + Lactated ringer's
Тяжесть: Противопоказано
Ceftriaxone and Lactated ringer's: contraindicated interaction.
Последнее обновление Источники: US FDA label
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Кратко
Ceftriaxone can form insoluble ceftriaxone-calcium precipitates when mixed with calcium-containing solutions such as lactated Ringer's. Fatal cases of lung and kidney crystal deposition have occurred in neonates. In neonates up to 28 days old, concurrent use is contraindicated, and in older patients the two must not be mixed or given simultaneously through the same line.
Что означает это взаимодействие простыми словами
Ceftriaxone and Lactated ringer's are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Почему это происходит
Physicochemical incompatibility: ceftriaxone binds calcium to form insoluble ceftriaxone-calcium salt that can precipitate in lines and in vivo.
Что делать
Do not give ceftriaxone to neonates (28 days or younger) who are receiving or expected to receive calcium-containing IV solutions.
О чём спросить фармацевта
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Источники
- Rocephin (ceftriaxone) Prescribing Information - Contraindications and Warnings: Interaction with Calcium-Containing Products — FDA Label
- Ceftriaxone Summary of Product Characteristics - Contraindications — EMA SmPC
Другие взаимодействия Ceftriaxone
- Calcium chloride + Ceftriaxone Противопоказано
- Calcium gluconate + Ceftriaxone Противопоказано
- Calcium + Ceftriaxone Противопоказано
- Ceftriaxone + Ringer's solution Противопоказано
- Calcium acetate + Ceftriaxone Тяжёлое
- Ceftriaxone + Lactated Ringer's solution Тяжёлое
Частые вопросы
Can I take Ceftriaxone with Lactated ringer's?
MediHelp rates the interaction as contraindicated. Ceftriaxone and Lactated ringer's are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ceftriaxone can form insoluble ceftriaxone-calcium precipitates when mixed with calcium-containing solutions such as lactated Ringer's. Fatal cases of lung and kidney crystal deposition have occurred in neonates. In neonates up to 28 days old, concurrent use is contraindicated, and in older patients the two must not be mixed or given simultaneously through the same line.
How serious is the interaction between Ceftriaxone and Lactated ringer's?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give ceftriaxone to neonates (28 days or younger) who are receiving or expected to receive calcium-containing IV solutions.
What other medicines interact with Ceftriaxone?
MediHelp also lists interactions of Ceftriaxone with, for example, Calcium chloride, Calcium gluconate, Calcium. The full list is on the Ceftriaxone page.
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