Лекарственные взаимодействия
Deflazacort + Measles mumps and rubella vaccine live
Тяжесть: Противопоказано
Deflazacort and Measles mumps and rubella vaccine live: contraindicated interaction.
Последнее обновление
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Кратко
The live attenuated MMR viruses may replicate excessively in patients immunosuppressed by deflazacort, risking vaccine-strain disease. The immune response may also be reduced.
Что означает это взаимодействие простыми словами
Deflazacort and Measles mumps and rubella vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Почему это происходит
Glucocorticoid immunosuppression impairs control of live attenuated viruses and reduces vaccine immunogenicity.
Что делать
Avoid during immunosuppressive corticosteroid therapy; give at least four weeks before starting steroids or after stopping for the interval in labeling. Check immunity and consider immunoglobulin after exposure.
О чём спросить фармацевта
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Другие взаимодействия Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Противопоказано
- Bcg vaccine live + Deflazacort Противопоказано
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Противопоказано
- Deflazacort + Measles mumps and rubella vaccine Противопоказано
- Deflazacort + Measles mumps rubella and varicella vaccine live Противопоказано
- Deflazacort + Measles vaccine Противопоказано
Частые вопросы
Can I take Deflazacort with Measles mumps and rubella vaccine live?
MediHelp rates the interaction as contraindicated. Deflazacort and Measles mumps and rubella vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The live attenuated MMR viruses may replicate excessively in patients immunosuppressed by deflazacort, risking vaccine-strain disease. The immune response may also be reduced.
How serious is the interaction between Deflazacort and Measles mumps and rubella vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid during immunosuppressive corticosteroid therapy; give at least four weeks before starting steroids or after stopping for the interval in labeling. Check immunity and consider immunoglobulin after exposure.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
Полные монографии, дозировки и проверка взаимодействий в приложении MediHelp
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