Drug interactions
Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir
Severity: Contraindicated
Ethinyl estradiol-drospirenone and Ombitasvir / paritaprevir / ritonavir: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinyl estradiol-containing contraceptives given with this HCV regimen have been associated with significant ALT elevations. The regimen is labeled as contraindicated with ethinyl estradiol products. The interaction is hepatic rather than a CYP3A4 effect of drospirenone.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Ombitasvir / paritaprevir / ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Mechanism of ALT elevation is not fully established; it is a labeled hepatotoxicity signal with ethinyl estradiol and this regimen.
What to do
Do not combine; switch to a progestin-only or non-hormonal contraceptive before starting the regimen. Ethinyl estradiol products may be resumed about 2 weeks after completing therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
- Anastrozole + Ethinyl estradiol-drospirenone Major
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Ombitasvir / paritaprevir / ritonavir?
MediHelp rates the interaction as contraindicated. Ethinyl estradiol-drospirenone and Ombitasvir / paritaprevir / ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ethinyl estradiol-containing contraceptives given with this HCV regimen have been associated with significant ALT elevations. The regimen is labeled as contraindicated with ethinyl estradiol products. The interaction is hepatic rather than a CYP3A4 effect of drospirenone.
How serious is the interaction between Ethinyl estradiol-drospirenone and Ombitasvir / paritaprevir / ritonavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; switch to a progestin-only or non-hormonal contraceptive before starting the regimen. Ethinyl estradiol products may be resumed about 2 weeks after completing therapy.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-drospirenone page.
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