Лекарственные взаимодействия
Nitroglycerin + Sildenafil
Тяжесть: Противопоказано
Nitroglycerin and Sildenafil: contraindicated interaction.
Последнее обновление Источники: US FDA label
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Кратко
Sildenafil greatly potentiates the vasodilator effect of nitrates, which can produce profound, prolonged hypotension, syncope, myocardial ischemia or infarction. Patients with coronary disease who use nitrates are the typical population at risk. Labeling of both drugs contraindicates the combination.
Что означает это взаимодействие простыми словами
Nitroglycerin and Sildenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Nitroglycerin belongs to Cardiovascular; Sildenafil belongs to Genitourinary.
Почему это происходит
Nitroglycerin releases nitric oxide to increase cGMP, while sildenafil inhibits PDE5-mediated cGMP breakdown, causing exaggerated vasodilation.
Что делать
Do not give nitrates to patients who have taken sildenafil within 24 hours. Patients with chest pain who recently took sildenafil need urgent medical assessment and non-nitrate approaches, and nitrates should be avoided for at least 24 hours after the dose.
О чём спросить фармацевта
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Источники
Другие взаимодействия Nitroglycerin
- Avanafil + Nitroglycerin Противопоказано
- Nitroglycerin + Riociguat Противопоказано
- Nitroglycerin + Tadalafil Противопоказано
- Nitroglycerin + Vardenafil Противопоказано
- Dihydroergotamine intranasal + Nitroglycerin Тяжёлое
- Dihydroergotamine + Nitroglycerin Тяжёлое
Другие взаимодействия Sildenafil
- Amyl nitrite + Sildenafil Противопоказано
- Atazanavir + Sildenafil Противопоказано
- Cobicistat + Sildenafil Противопоказано
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Противопоказано
- Glyceryl trinitrate pr + Sildenafil Противопоказано
- Isosorbide dinitrate + Sildenafil Противопоказано
Частые вопросы
Can I take Nitroglycerin with Sildenafil?
MediHelp rates the interaction as contraindicated. Nitroglycerin and Sildenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sildenafil greatly potentiates the vasodilator effect of nitrates, which can produce profound, prolonged hypotension, syncope, myocardial ischemia or infarction. Patients with coronary disease who use nitrates are the typical population at risk. Labeling of both drugs contraindicates the combination.
How serious is the interaction between Nitroglycerin and Sildenafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give nitrates to patients who have taken sildenafil within 24 hours. Patients with chest pain who recently took sildenafil need urgent medical assessment and non-nitrate approaches, and nitrates should be avoided for at least 24 hours after the dose.
What other medicines interact with Nitroglycerin?
MediHelp also lists interactions of Nitroglycerin with, for example, Avanafil, Riociguat, Tadalafil. The full list is on the Nitroglycerin page.
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