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Лекарственные взаимодействия

Ozanimod + Procarbazine

Тяжесть: Противопоказано

Ozanimod and Procarbazine: contraindicated interaction.

Последнее обновление

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Кратко

Ozanimod's active metabolites are formed and cleared through pathways involving MAO-B, and the labeling advises against use with MAO inhibitors. Procarbazine's MAO inhibition could alter exposure to these metabolites and may raise the risk of a hypertensive reaction. Procarbazine also adds immunosuppression and myelosuppression to the effects of ozanimod.

Что означает это взаимодействие простыми словами

Ozanimod and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Ozanimod belongs to Central Nervous System; Procarbazine belongs to Oncology.

Уровень доказательности: Low

Почему это происходит

MAO inhibition may alter ozanimod metabolite exposure and increases the risk of a hypertensive reaction through added sympathomimetic effects.

Что делать

Do not use together. Allow at least 14 days between stopping either drug and starting the other.

О чём спросить фармацевта

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
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Частые вопросы

Can I take Ozanimod with Procarbazine?

MediHelp rates the interaction as contraindicated. Ozanimod and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ozanimod's active metabolites are formed and cleared through pathways involving MAO-B, and the labeling advises against use with MAO inhibitors. Procarbazine's MAO inhibition could alter exposure to these metabolites and may raise the risk of a hypertensive reaction. Procarbazine also adds immunosuppression and myelosuppression to the effects of ozanimod.

How serious is the interaction between Ozanimod and Procarbazine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Allow at least 14 days between stopping either drug and starting the other.

What other medicines interact with Procarbazine?

MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.

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