Лекарственные взаимодействия
Ozanimod + Safinamide
Тяжесть: Противопоказано
Ozanimod and Safinamide: contraindicated interaction.
Последнее обновление
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Кратко
Ozanimod's active metabolites are formed partly via MAO-B, and inhibition may change exposure and could allow nonselective MAO inhibition. Hypertensive crisis is a theoretical risk, and the clinical interaction has not been fully studied.
Что означает это взаимодействие простыми словами
Ozanimod and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ozanimod belongs to Central Nervous System; Safinamide belongs to Central Nervous System.
Почему это происходит
MAO-B inhibition alters formation of ozanimod's active metabolites, which may also inhibit MAO, creating a risk of excess adrenergic stimulation.
Что делать
Avoid concurrent use as per ozanimod labeling. Allow at least 14 days between stopping one and starting the other.
О чём спросить фармацевта
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Другие взаимодействия Safinamide
- Amitriptyline + Safinamide Противопоказано
- Amoxapine + Safinamide Противопоказано
- Amphetamine polistirex + Safinamide Противопоказано
- Clomipramine + Safinamide Противопоказано
- Cyclobenzaprine + Safinamide Противопоказано
- Desipramine + Safinamide Противопоказано
Другие взаимодействия Ozanimod
- Isocarboxazid + Ozanimod Противопоказано
- Linezolid + Ozanimod Противопоказано
- Ozanimod + Phenelzine Противопоказано
- Ozanimod + Procarbazine Противопоказано
- Ozanimod + Rasagiline Противопоказано
- Ozanimod + Tranylcypromine Противопоказано
Частые вопросы
Can I take Ozanimod with Safinamide?
MediHelp rates the interaction as contraindicated. Ozanimod and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ozanimod's active metabolites are formed partly via MAO-B, and inhibition may change exposure and could allow nonselective MAO inhibition. Hypertensive crisis is a theoretical risk, and the clinical interaction has not been fully studied.
How serious is the interaction between Ozanimod and Safinamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use as per ozanimod labeling. Allow at least 14 days between stopping one and starting the other.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
Полные монографии, дозировки и проверка взаимодействий в приложении MediHelp
Откройте полный справочник, проверяйте взаимодействия нескольких препаратов и пользуйтесь инструментами дозирования в приложении MediHelp.
