Drug interactions
Ozanimod + Procarbazine
Severity: Contraindicated
Ozanimod and Procarbazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod's active metabolites are formed and cleared through pathways involving MAO-B, and the labeling advises against use with MAO inhibitors. Procarbazine's MAO inhibition could alter exposure to these metabolites and may raise the risk of a hypertensive reaction. Procarbazine also adds immunosuppression and myelosuppression to the effects of ozanimod.
What this interaction means in plain words
Ozanimod and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ozanimod belongs to Central Nervous System; Procarbazine belongs to Oncology.
Why it happens
MAO inhibition may alter ozanimod metabolite exposure and increases the risk of a hypertensive reaction through added sympathomimetic effects.
What to do
Do not use together. Allow at least 14 days between stopping either drug and starting the other.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
- Ozanimod + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Ozanimod with Procarbazine?
MediHelp rates the interaction as contraindicated. Ozanimod and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ozanimod's active metabolites are formed and cleared through pathways involving MAO-B, and the labeling advises against use with MAO inhibitors. Procarbazine's MAO inhibition could alter exposure to these metabolites and may raise the risk of a hypertensive reaction. Procarbazine also adds immunosuppression and myelosuppression to the effects of ozanimod.
How serious is the interaction between Ozanimod and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Allow at least 14 days between stopping either drug and starting the other.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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