Лекарственные взаимодействия
Riociguat + Sildenafil
Тяжесть: Противопоказано
Riociguat and Sildenafil: contraindicated interaction.
Последнее обновление Источники: US FDA label
Для специалистов здравоохранения — только для справки. Эта страница — краткая сводка, а не медицинская консультация и не замена официальной инструкции или клинического суждения. Всегда проверяйте перед назначением или отпуском.
Клиническое содержание этой страницы доступно только на английском языке.
Кратко
Combining riociguat with PDE5 inhibitors such as sildenafil causes additive systemic vasodilation and can lead to hypotension. In a pulmonary arterial hypertension study, adding riociguat to sildenafil showed no favorable benefit and was associated with unfavorable outcomes including more deaths. Riociguat labeling contraindicates concomitant PDE5 inhibitors.
Что означает это взаимодействие простыми словами
Riociguat and Sildenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Riociguat belongs to Cardiovascular; Sildenafil belongs to Genitourinary.
Почему это происходит
Riociguat stimulates soluble guanylate cyclase to raise cGMP, and sildenafil blocks cGMP degradation via PDE5, so the effects on the nitric oxide-cGMP pathway are additive.
Что делать
Do not use the two together. When switching, stop sildenafil at least 24 hours before starting riociguat, and consider specialist guidance on the transition.
О чём спросить фармацевта
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Для подписчиков Pro+
Откройте страницу целиком
Создайте аккаунт и начните пробный период Pro+, чтобы открыть полные рекомендации по ведению для Riociguat и Sildenafil, дополнительные примечания, подробности о доказательной базе и проверку взаимодействий для всего рецепта.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ бесплатно 14 дней на сайте. Карта не нужна.
Источники
- Adempas (riociguat) Prescribing Information - Contraindications — FDA Label
- Adempas (riociguat) Summary of Product Characteristics — EMA SmPC
Другие взаимодействия Riociguat
- Avanafil + Riociguat Противопоказано
- Dipyridamole + Riociguat Противопоказано
- Isosorbide dinitrate + Riociguat Противопоказано
- Isosorbide mononitrate + Riociguat Противопоказано
- Nitroglycerin + Riociguat Противопоказано
- Riociguat + Tadalafil Противопоказано
Другие взаимодействия Sildenafil
- Amyl nitrite + Sildenafil Противопоказано
- Atazanavir + Sildenafil Противопоказано
- Cobicistat + Sildenafil Противопоказано
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Противопоказано
- Glyceryl trinitrate pr + Sildenafil Противопоказано
- Isosorbide dinitrate + Sildenafil Противопоказано
Частые вопросы
Can I take Riociguat with Sildenafil?
MediHelp rates the interaction as contraindicated. Riociguat and Sildenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining riociguat with PDE5 inhibitors such as sildenafil causes additive systemic vasodilation and can lead to hypotension. In a pulmonary arterial hypertension study, adding riociguat to sildenafil showed no favorable benefit and was associated with unfavorable outcomes including more deaths. Riociguat labeling contraindicates concomitant PDE5 inhibitors.
How serious is the interaction between Riociguat and Sildenafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use the two together. When switching, stop sildenafil at least 24 hours before starting riociguat, and consider specialist guidance on the transition.
What other medicines interact with Riociguat?
MediHelp also lists interactions of Riociguat with, for example, Avanafil, Dipyridamole, Isosorbide dinitrate. The full list is on the Riociguat page.
Полные монографии, дозировки и проверка взаимодействий в приложении MediHelp
Откройте полный справочник, проверяйте взаимодействия нескольких препаратов и пользуйтесь инструментами дозирования в приложении MediHelp.
