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Colchicine + Ritonavir

شدت: مانع استعمال

Colchicine and Ritonavir: contraindicated interaction.

آخری تازہ کاری ماخذ: US FDA label

صرف صحت کے پیشہ ور افراد کے لیے — محض حوالے کے طور پر۔ یہ صفحہ مختصر خلاصہ ہے، طبی مشورہ نہیں، اور سرکاری لیبل یا طبی فیصلے کا متبادل نہیں۔ تجویز یا فراہمی سے پہلے ہمیشہ تصدیق کریں۔

اس صفحے کا طبی مواد صرف انگریزی میں دستیاب ہے۔

خلاصہ

Ritonavir substantially increases colchicine exposure, and life-threatening or fatal colchicine toxicity has been reported. Toxicity may include severe gastrointestinal illness, rhabdomyolysis, pancytopenia and multiorgan failure. The combination is contraindicated in patients with renal or hepatic impairment and requires major dose reduction in others.

اس تعامل کا آسان لفظوں میں مطلب

Colchicine and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Colchicine belongs to Genitourinary; Ritonavir belongs to Anti Virals.

شواہد کی سطح: High

ایسا کیوں ہوتا ہے

Ritonavir is a potent CYP3A4 and P-glycoprotein inhibitor, which markedly reduces colchicine clearance.

کیا کرنا ہے

Do not combine in patients with renal or hepatic impairment. In patients with normal organ function where co-administration cannot be avoided, follow the labeled markedly reduced colchicine dosing and avoid repeating flare treatment for several days.

فارماسسٹ سے کیا پوچھیں

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ اراکین کے لیے

پورا صفحہ کھولیں

Colchicine اور Ritonavir کے لیے مکمل طبی انتظام کی رہنمائی، اضافی نوٹس، شواہد کی تفصیل اور پورے نسخے کا تعامل چیکر کھولنے کے لیے اکاؤنٹ بنائیں اور Pro+ ٹرائل شروع کریں۔

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

ویب پر 14 دن تک Pro+ مفت آزمائیں۔ کارڈ کی ضرورت نہیں۔

حوالہ جات

اکثر پوچھے جانے والے سوالات

Can I take Colchicine with Ritonavir?

MediHelp rates the interaction as contraindicated. Colchicine and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ritonavir substantially increases colchicine exposure, and life-threatening or fatal colchicine toxicity has been reported. Toxicity may include severe gastrointestinal illness, rhabdomyolysis, pancytopenia and multiorgan failure. The combination is contraindicated in patients with renal or hepatic impairment and requires major dose reduction in others.

How serious is the interaction between Colchicine and Ritonavir?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine in patients with renal or hepatic impairment. In patients with normal organ function where co-administration cannot be avoided, follow the labeled markedly reduced colchicine dosing and avoid repeating flare treatment for several days.

What other medicines interact with Colchicine?

MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.

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