藥品參考
Atrasentan
Atrasentan is a medicine in the class miscellaneous. It is used for nephropathy.
- 藥物類別: Miscellaneous
- 用途: nephropathy
最後更新 來源: US FDA label
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Miscellaneous
- 常見劑型
- 錠劑
- 常見規格
- 0.75 mg
- 商品名
- 1
- 國家與市場
- 1
用途
作用方式
Atrasentan is an endothelin type A (ET A) receptor antagonist with >1800-fold selectivity for ET A over the endothelin type B receptor. Endothelin-1 is thought to contribute to IgAN pathogenesis via the ET A receptor.
成人常用劑量（仿單摘要）
Reduction of proteinuria in primary IgAN: 0.75 mg orally once daily with or without food.
懷孕與哺乳
- 懷孕
- Unsafe Contraindicated; animal studies show teratogenicity and fetal harm including birth defects and fetal death.
- 哺乳
- Unsafe No human milk data; advise not to breastfeed during treatment because of potential adverse reactions such as fluid retention in infants.
已通報的副作用
- Peripheral edema
- Anemia
- Liver transaminase elevation
黑框警語
- Embryo-fetal toxicity: contraindicated in pregnancy; may cause major birth defects based on animal data. Exclude pregnancy before starting. Use effective contraception before, during, and for two weeks after treatment. Stop as soon as possible if pregnancy occurs.
禁忌症
- Pregnancy.
- History of hypersensitivity reaction to atrasentan or any component of the product.
哪些人需要特別留意
- Embryo-fetal toxicity: may cause fetal harm; exclude pregnancy before starting and use effective contraception.
- Hepatotoxicity: obtain liver enzymes before starting and as clinically indicated; do not initiate in severe hepatic impairment; discontinue if clinically relevant aminotransferase elevations occur.
- Fluid retention: not evaluated in IgAN patients with heart failure; if significant, consider diuretic and interrupting treatment.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
常見問題
What is Atrasentan used for?
Atrasentan is a medicine in the class miscellaneous. It is used for Nephropathy.
What side effects have been reported with Atrasentan?
Peripheral edema, Anemia, Liver transaminase elevation. Serious warning: Embryo-fetal toxicity: contraindicated in pregnancy; may cause major birth defects based on animal data.
Can Atrasentan be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Contraindicated; animal studies show teratogenicity and fetal harm including birth defects and fetal death. Breastfeeding: Unsafe. No human milk data; advise not to breastfeed during treatment because of potential adverse reactions such as fluid retention in infants.
What does Atrasentan interact with?
MediHelp does not list a checked interaction for Atrasentan yet. Always tell your pharmacist about every medicine you take.
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