藥品參考
Daraxonrasib
Daraxonrasib is a medicine in the class oncology. It is used for pancreatic cancer.
- 藥物類別: Oncology
- 用途: pancreatic cancer
最後更新 來源: US FDA label
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Oncology
- 常見劑型
- 錠劑
- 商品名
- 1
- 國家與市場
- 1
用途
作用方式
Inhibitor of the RAS GTPase family. It binds cyclophilin A, and the resulting complex binds active GTP-bound RAS, blocking downstream effector interactions and promoting GTP hydrolysis to inactive GDP-bound RAS.
成人常用劑量（仿單摘要）
Metastatic pancreatic adenocarcinoma (after at least one prior systemic therapy or not a candidate for multiagent therapy): 300 mg orally once daily at the same time each day, with or without food, until disease progression or unacceptable toxicity
懷孕與哺乳
- 懷孕
- Unsafe Can cause fetal harm: in mice it caused fetal death, growth changes and malformations at exposures 2.5 times the human dose; no human data. Avoid in pregnancy; check pregnancy status before starting and use effective contraception during treatment and for 1 week after the last dose.
- 哺乳
- Unsafe No data on milk levels or infant effects. Because of possible serious reactions in the infant, do not breastfeed during treatment and for 1 week after the last dose.
已通報的副作用
- Rash
- Diarrhea
- Stomatitis
- Nausea
- Fatigue
- Vomiting
哪些人需要特別留意
- Dermatologic and soft tissue toxicity (rash, pruritus, paronychia, dry skin), which may be severe. Use prophylaxis before the first dose and limit sun exposure.
- Stomatitis and oral disorders, including mouth ulcers and oral mucositis. Monitor and treat with a steroid-containing mouthwash.
- Diarrhea: give antidiarrheal treatment as clinically indicated, and withhold, reduce or discontinue based on severity.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
常見問題
What is Daraxonrasib used for?
Daraxonrasib is a medicine in the class oncology. It is used for Pancreatic cancer.
What side effects have been reported with Daraxonrasib?
Rash, Diarrhea, Stomatitis, Nausea, Fatigue, Vomiting.
Can Daraxonrasib be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm: in mice it caused fetal death, growth changes and malformations at exposures 2.5 times the human dose; no human data. Avoid in pregnancy; check pregnancy status before starting and use effective contraception during treatment and for 1 week after the last dose. Breastfeeding: Unsafe. No data on milk levels or infant effects. Because of possible serious reactions in the infant, do not breastfeed during treatment and for 1 week after the last dose.
What does Daraxonrasib interact with?
MediHelp does not list a checked interaction for Daraxonrasib yet. Always tell your pharmacist about every medicine you take.
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