藥品參考
Lazertinib
Lazertinib is a medicine in the class oncology. It is used for non-small cell lung cancer.
- 藥物類別: Oncology
- 用途: non-small cell lung cancer
最後更新 來源: US FDA label
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Oncology
- ATC 代碼
- L01EB09
- 常見劑型
- 錠劑
- 已知交互作用
- 1 (中度: 1)
- 商品名
- 2
- 國家與市場
- 2
用途
作用方式
Kinase inhibitor of EGFR that inhibits EGFR exon 19 deletions and exon 21 L858R substitution mutations at lower concentrations than wild-type EGFR.
成人常用劑量（仿單摘要）
First-line EGFR-mutated NSCLC (exon 19 deletion or exon 21 L858R), with amivantamab: 240 mg orally once daily with or without food; continue until disease progression or unacceptable toxicity; give any time prior to amivantamab on the same day.
懷孕與哺乳
- 懷孕
- Unsafe Can cause fetal harm: no human data; in animals it reduced embryo-fetal survival and fetal weight (rats) and caused malformations (rabbits) at about 4 and 0.5 times human exposure. Verify pregnancy status and use effective contraception during and for 3 weeks after treatment.
- 哺乳
- Unsafe No data on milk levels or infant effects. Because of possible serious adverse reactions in the infant, do not breastfeed during treatment and for 3 weeks after the last dose; follow the amivantamab label for the combination.
已通報的副作用
- Rash
- Nail toxicity
- Musculoskeletal pain
- Edema
- Stomatitis
- Venous thromboembolism
禁忌症
- None.
哪些人需要特別留意
- Serious and fatal VTE (36% in MARIPOSA); give prophylactic anticoagulation for the first four months; vitamin K antagonists are not recommended.
- ILD/pneumonitis can occur; monitor for symptoms, withhold if suspected, discontinue if confirmed.
- Severe dermatologic reactions including rash; prophylactic measures recommended; limit sun exposure.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (1)
- Amivantamab + Lazertinib Moderate
Pro+ 會員專屬
解鎖完整頁面
建立帳號並開始 Pro+ 試用，即可開啟 Lazertinib 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
在網頁版免費試用 Pro+ 14 天，無需信用卡。
同類別的其他藥品
常見問題
What is Lazertinib used for?
Lazertinib is a medicine in the class oncology. It is used for Non-small cell lung cancer.
What side effects have been reported with Lazertinib?
Rash, Nail toxicity, Musculoskeletal pain, Edema, Stomatitis, Venous thromboembolism.
Can Lazertinib be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm: no human data; in animals it reduced embryo-fetal survival and fetal weight (rats) and caused malformations (rabbits) at about 4 and 0.5 times human exposure. Verify pregnancy status and use effective contraception during and for 3 weeks after treatment. Breastfeeding: Unsafe. No data on milk levels or infant effects. Because of possible serious adverse reactions in the infant, do not breastfeed during treatment and for 3 weeks after the last dose; follow the amivantamab label for the combination.
What does Lazertinib interact with?
MediHelp lists 1 known interactions for Lazertinib. Moderate: 1. The most serious include Amivantamab.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
