藥品參考
Selpercatinib
Selpercatinib is a medicine in the class oncology. It is used for cancer.
- 藥物類別: Oncology
- 用途: cancer
最後更新 來源: EMA SmPC
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Oncology
- ATC 代碼
- L01EX22
- 常見劑型
- 錠劑, 膠囊
- 常見規格
- 40 mg
- 已知交互作用
- 123 (嚴重: 72 · 中度: 51)
- 商品名
- 3
- 國家與市場
- 3
用途
作用方式
Selpercatinib is an inhibitor of the RET receptor tyrosine kinase. It also inhibited VEGFR1 and VEGFR3 and, at higher concentrations, FGFR 1, 2 and 3.
成人常用劑量（仿單摘要）
RET fusion-positive/RET-mutant tumours (patients 12 years and older, under 50 kg): 120 mg orally twice daily until disease progression or unacceptable toxicity
懷孕與哺乳
- 懷孕
- Unsafe Can cause fetal harm: in rats it caused embryo death and malformations at about human exposure. No human data. EU label: not recommended in pregnancy or without contraception. Check pregnancy status; use highly effective contraception during and for at least 1 week after.
- 哺乳
- Unsafe No human milk data. LactMed: 97% protein bound, so milk levels are likely low. Because of possible serious infant reactions, US and EU labels say do not breastfeed during treatment and for 1 week after the last dose.
已通報的副作用
- Hypertension
- Increased AST
- Increased ALT
- Diarrhoea
- Fatigue
- Oedema
禁忌症
- Hypersensitivity to the active substance or to any excipient.
哪些人需要特別留意
- Severe, life-threatening or fatal ILD/pneumonitis; withhold, investigate and adjust or discontinue.
- Increased ALT/AST: monitor before treatment, every 2 weeks for 3 months, then monthly for 3 months.
- Hypertension: control blood pressure before starting and monitor; discontinue permanently if it cannot be controlled.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (123)
- Amiodarone + Selpercatinib Major
- Amisulpride + Selpercatinib Major
- Amitriptyline + Selpercatinib Major
- Amobarbital + Selpercatinib Major
- Anagrelide + Selpercatinib Major
- Apalutamide + Selpercatinib Major
- Asenapine + Selpercatinib Major
- Buprenorphine + Selpercatinib Major
- Carbamazepine + Selpercatinib Major
- Chloroquine + Selpercatinib Major
Pro+ 會員專屬
解鎖完整頁面
建立帳號並開始 Pro+ 試用，即可開啟 Selpercatinib 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
在網頁版免費試用 Pro+ 14 天，無需信用卡。
同類別的其他藥品
常見問題
What is Selpercatinib used for?
Selpercatinib is a medicine in the class oncology. It is used for Cancer, Non-small cell lung cancer, Thyroid cancer.
What side effects have been reported with Selpercatinib?
Hypertension, Increased AST, Increased ALT, Diarrhoea, Fatigue, Oedema.
Can Selpercatinib be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm: in rats it caused embryo death and malformations at about human exposure. No human data. EU label: not recommended in pregnancy or without contraception. Check pregnancy status; use highly effective contraception during and for at least 1 week after. Breastfeeding: Unsafe. No human milk data. LactMed: 97% protein bound, so milk levels are likely low. Because of possible serious infant reactions, US and EU labels say do not breastfeed during treatment and for 1 week after the last dose.
What does Selpercatinib interact with?
MediHelp lists 123 known interactions for Selpercatinib. Major: 72 · Moderate: 51. The most serious include Amiodarone, Amisulpride, Amitriptyline.
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