藥品參考
Thyrotropin alfa
Thyrotropin alfa is a medicine in the class endocrine. It is used for thyroid cancer.
- 藥物類別: Endocrine
- 用途: thyroid cancer
最後更新 來源: US FDA label
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Endocrine
- ATC 代碼
- H01AB01
- 常見劑型
- 注射劑
- 常見規格
- 0.9 mg/ml
- 商品名
- 3
- 國家與市場
- 3
用途
作用方式
Thyrotropin alfa binds TSH receptors on normal thyroid epithelial cells or well-differentiated thyroid cancer tissue, stimulating iodine uptake and organification and synthesis and secretion of thyroglobulin, T3 and T4. This increases radioiodine uptake for scan detection or radioiodine killing of thyroid cells.
成人常用劑量（仿單摘要）
Adjunctive diagnostic tool or adjunct for thyroid remnant ablation in well-differentiated thyroid cancer: 0.9 mg intramuscular injection to the buttock, followed by a second 0.9 mg intramuscular injection 24 hours later; intramuscular only, not intravenous
懷孕與哺乳
- 懷孕
- Unsafe Used with radioiodine, it is contraindicated in pregnancy (UK label) because the fetus would be exposed to radiation, which can cause permanent thyroid damage. Data on thyrotropin alfa alone are too few to assess risk; no animal studies. Exclude pregnancy before use.
- 哺乳
- Unsafe With radioiodine: contraindicated (therapy) or stop breastfeeding after the dose (diagnosis), because of radiation to the infant and breast. Alone: no milk data; UK label says do not use while breastfeeding; US label: weigh benefits. Large protein, unlikely to reach the infant.
已通報的副作用
- Nausea
- Headache
- Fatigue
- Vomiting
- Dizziness
- Asthenia
禁忌症
- When given with radioiodine, the contraindications to radioiodine also apply to the combination regimen.
- Combination with radioiodine is contraindicated in pregnancy.
- Concomitant use with therapeutic radioiodine is contraindicated in lactating women.
哪些人需要特別留意
- Hyperthyroidism: transient significant rise in thyroid hormone in patients with substantial thyroid tissue in situ or functional metastases; deaths reported. Elderly and heart disease patients are at risk; consider hospitalization and observation.
- Stroke reported within 72 hours of administration, mostly in young women taking oral contraceptives or with other stroke risk factors. Ensure patients are well hydrated beforehand.
- Sudden rapid painful tumor enlargement may occur (hemiplegia, hemiparesis, vision loss, laryngeal edema, respiratory distress). Consider glucocorticoid pretreatment.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
Pro+ 會員專屬
解鎖完整頁面
建立帳號並開始 Pro+ 試用，即可開啟 Thyrotropin alfa 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
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同類別的其他藥品
常見問題
What is Thyrotropin alfa used for?
Thyrotropin alfa is a medicine in the class endocrine. It is used for Thyroid cancer.
What side effects have been reported with Thyrotropin alfa?
Nausea, Headache, Fatigue, Vomiting, Dizziness, Asthenia.
Can Thyrotropin alfa be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Used with radioiodine, it is contraindicated in pregnancy (UK label) because the fetus would be exposed to radiation, which can cause permanent thyroid damage. Data on thyrotropin alfa alone are too few to assess risk; no animal studies. Exclude pregnancy before use. Breastfeeding: Unsafe. With radioiodine: contraindicated (therapy) or stop breastfeeding after the dose (diagnosis), because of radiation to the infant and breast. Alone: no milk data; UK label says do not use while breastfeeding; US label: weigh benefits. Large protein, unlikely to reach the infant.
What does Thyrotropin alfa interact with?
MediHelp does not list a checked interaction for Thyrotropin alfa yet. Always tell your pharmacist about every medicine you take.
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