藥品參考
Trametinib
Trametinib is a medicine in the class oncology. It is used for melanoma.
- 藥物類別: Oncology
- 用途: melanoma
最後更新 來源: US FDA label
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Oncology
- ATC 代碼
- L01EE01
- 常見劑型
- 錠劑, 溶液
- 常見規格
- 0.5 mg
- 已知交互作用
- 1 (輕微: 1)
- 商品名
- 4
- 國家與市場
- 3
用途
作用方式
Trametinib is a reversible inhibitor of MEK1 and MEK2 activation and kinase activity. MEK proteins are upstream regulators of the ERK pathway, which promotes cellular proliferation.
成人常用劑量（仿單摘要）
Adults, all approved indications (tablets): 2 mg orally once daily, until disease progression or unacceptable toxicity; adjuvant melanoma up to 1 year
懷孕與哺乳
- 懷孕
- Unsafe Can cause fetal harm: in rabbits it was embryotoxic and caused abortion at about 0.3 times human exposure; human data are insufficient. Check pregnancy status; contraception during treatment and for 4 months after the last dose (men with female partners: condoms for 4 months).
- 哺乳
- Unsafe No human milk data. Highly protein bound, but its half-life of about 4 to 5 days could let it build up in the infant. Do not breastfeed during treatment and for 4 months after the last dose.
已通報的副作用
- Rash
- Diarrhea
- Lymphedema
- Pyrexia
- Nausea
- Vomiting
禁忌症
- None.
哪些人需要特別留意
- New primary cutaneous and non-cutaneous malignancies can occur when used with dabrafenib; monitor patients.
- Hemorrhage, including fatal major hemorrhage, can occur.
- Colitis and gastrointestinal perforation can occur.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (1)
Pro+ 會員專屬
解鎖完整頁面
建立帳號並開始 Pro+ 試用，即可開啟 Trametinib 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
在網頁版免費試用 Pro+ 14 天，無需信用卡。
同類別的其他藥品
常見問題
What is Trametinib used for?
Trametinib is a medicine in the class oncology. It is used for Melanoma, Non-small cell lung cancer, Thyroid cancer.
What side effects have been reported with Trametinib?
Rash, Diarrhea, Lymphedema, Pyrexia, Nausea, Vomiting.
Can Trametinib be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm: in rabbits it was embryotoxic and caused abortion at about 0.3 times human exposure; human data are insufficient. Check pregnancy status; contraception during treatment and for 4 months after the last dose (men with female partners: condoms for 4 months). Breastfeeding: Unsafe. No human milk data. Highly protein bound, but its half-life of about 4 to 5 days could let it build up in the infant. Do not breastfeed during treatment and for 4 months after the last dose.
What does Trametinib interact with?
MediHelp lists 1 known interactions for Trametinib. Minor: 1. The most serious include Dichlorphenamide.
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