藥物交互作用
Adenovirus types 4 and 7 live + Doxorubicin
嚴重程度: 嚴重
Adenovirus types 4 and 7 live and Doxorubicin: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Doxorubicin causes myelosuppression and immunosuppression, which can blunt the response to the live oral adenovirus vaccine. The attenuated virus may also replicate more extensively in an immunocompromised patient, raising the risk of vaccine-related infection.
用白話說明這項交互作用的意義
Adenovirus types 4 and 7 live and Doxorubicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Cytotoxic immunosuppression impairs vaccine immune response and permits uncontrolled replication of the live attenuated virus.
處置方式
Avoid live vaccines during chemotherapy and for at least 3 months after it ends, or until immune recovery is confirmed. Use non-live vaccines where an alternative exists.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Doxorubicin 的其他交互作用
常見問題
Can I take Adenovirus types 4 and 7 live with Doxorubicin?
MediHelp rates the interaction as major. Adenovirus types 4 and 7 live and Doxorubicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Doxorubicin causes myelosuppression and immunosuppression, which can blunt the response to the live oral adenovirus vaccine. The attenuated virus may also replicate more extensively in an immunocompromised patient, raising the risk of vaccine-related infection.
How serious is the interaction between Adenovirus types 4 and 7 live and Doxorubicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during chemotherapy and for at least 3 months after it ends, or until immune recovery is confirmed. Use non-live vaccines where an alternative exists.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Belatacept, Cobicistat, Cyclophosphamide. The full list is on the Doxorubicin page.
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