藥物交互作用
Adenovirus types 4 and 7 live + Fluorouracil
嚴重程度: 嚴重
Adenovirus types 4 and 7 live and Fluorouracil: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Fluorouracil causes myelosuppression and immunosuppression, so a live oral adenovirus vaccine may replicate excessively and cause disease. The vaccine response may also be blunted.
用白話說明這項交互作用的意義
Adenovirus types 4 and 7 live and Fluorouracil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Cytotoxic immunosuppression impairs control of live-attenuated virus and reduces vaccine immunogenicity.
處置方式
Do not give the live vaccine during chemotherapy; defer vaccination until at least about 3 months after chemotherapy ends and immune recovery is confirmed.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Fluorouracil 的其他交互作用
常見問題
Can I take Adenovirus types 4 and 7 live with Fluorouracil?
MediHelp rates the interaction as major. Adenovirus types 4 and 7 live and Fluorouracil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluorouracil causes myelosuppression and immunosuppression, so a live oral adenovirus vaccine may replicate excessively and cause disease. The vaccine response may also be blunted.
How serious is the interaction between Adenovirus types 4 and 7 live and Fluorouracil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give the live vaccine during chemotherapy; defer vaccination until at least about 3 months after chemotherapy ends and immune recovery is confirmed.
What other medicines interact with Fluorouracil?
MediHelp also lists interactions of Fluorouracil with, for example, Axicabtagene ciloleucel, Belatacept, Brexucabtagene autoleucel. The full list is on the Fluorouracil page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
