藥物交互作用
Alogliptin-pioglitazone + Daprodustat
嚴重程度: 中度
Alogliptin-pioglitazone and Daprodustat: moderate interaction.
最後更新
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摘要
Pioglitazone is a weak CYP2C8 inhibitor, whereas daprodustat is a CYP2C8 substrate whose exposure rises with strong inhibitors such as gemfibrozil. A modest increase in daprodustat levels is possible, which could increase hemoglobin and thrombotic risk.
用白話說明這項交互作用的意義
Alogliptin-pioglitazone and Daprodustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alogliptin-pioglitazone belongs to Endocrine; Daprodustat belongs to Endocrine.
為什麼會發生
Inhibition of CYP2C8-mediated daprodustat metabolism.
處置方式
Monitor hemoglobin and adjust the daprodustat dose accordingly when pioglitazone is started or stopped.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Alogliptin-pioglitazone 的其他交互作用
Daprodustat 的其他交互作用
常見問題
Can I take Alogliptin-pioglitazone with Daprodustat?
MediHelp rates the interaction as moderate. Alogliptin-pioglitazone and Daprodustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pioglitazone is a weak CYP2C8 inhibitor, whereas daprodustat is a CYP2C8 substrate whose exposure rises with strong inhibitors such as gemfibrozil. A modest increase in daprodustat levels is possible, which could increase hemoglobin and thrombotic risk.
How serious is the interaction between Alogliptin-pioglitazone and Daprodustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and adjust the daprodustat dose accordingly when pioglitazone is started or stopped.
What other medicines interact with Alogliptin-pioglitazone?
MediHelp also lists interactions of Alogliptin-pioglitazone with, for example, Gemfibrozil, Insulin aspart, Insulin degludec. The full list is on the Alogliptin-pioglitazone page.
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