藥物交互作用
Amiloride + Meloxicam
嚴重程度: 嚴重
Amiloride and Meloxicam: major interaction.
最後更新 來源: UK SmPC
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摘要
Both drugs can raise serum potassium, and NSAIDs may also blunt the diuretic effect and impair renal function. Hyperkalemia risk is greatest in older patients and those with renal impairment or diabetes.
用白話說明這項交互作用的意義
Amiloride and Meloxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiloride belongs to Cardiovascular; Meloxicam belongs to Musculoskeletal.
為什麼會發生
Amiloride blocks renal potassium secretion while NSAIDs reduce renin and aldosterone and renal blood flow, additively impairing potassium excretion.
處置方式
Avoid the combination in renal impairment. Otherwise monitor serum potassium and creatinine closely, especially at initiation.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
參考資料
- Meloxicam 15 mg Tablets - SmPC sections 4.3/4.5 (class statement: potassium-sparing diuretics; "Certain medicinal products or therapeutic groups may promote hyperkalemia: potassium salts, potassium-sparing diuretics, angiotensin-converting enzyme (ACE) inh") — electronic medicines compendium (UK SmPC)
Meloxicam 的其他交互作用
Amiloride 的其他交互作用
常見問題
Can I take Amiloride with Meloxicam?
MediHelp rates the interaction as major. Amiloride and Meloxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can raise serum potassium, and NSAIDs may also blunt the diuretic effect and impair renal function. Hyperkalemia risk is greatest in older patients and those with renal impairment or diabetes.
How serious is the interaction between Amiloride and Meloxicam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in renal impairment. Otherwise monitor serum potassium and creatinine closely, especially at initiation.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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