藥物交互作用
Amoxapine + Phenelzine
嚴重程度: 禁忌併用
Amoxapine and Phenelzine: contraindicated interaction.
最後更新
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摘要
Combining an MAO inhibitor with amoxapine, which inhibits monoamine reuptake, can cause serotonin syndrome and hypertensive crises. Severe reactions including hyperthermia and seizures have been described with antidepressant-MAOI combinations.
用白話說明這項交互作用的意義
Amoxapine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
MAO inhibition combined with reuptake inhibition causes excess synaptic serotonin and norepinephrine.
處置方式
Do not combine; allow at least 14 days after stopping phenelzine before starting amoxapine, and an adequate washout after stopping amoxapine before phenelzine.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Phenelzine 的其他交互作用
常見問題
Can I take Amoxapine with Phenelzine?
MediHelp rates the interaction as contraindicated. Amoxapine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining an MAO inhibitor with amoxapine, which inhibits monoamine reuptake, can cause serotonin syndrome and hypertensive crises. Severe reactions including hyperthermia and seizures have been described with antidepressant-MAOI combinations.
How serious is the interaction between Amoxapine and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; allow at least 14 days after stopping phenelzine before starting amoxapine, and an adequate washout after stopping amoxapine before phenelzine.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Atomoxetine. The full list is on the Phenelzine page.
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