藥物交互作用
Atomoxetine + Selegiline transdermal
嚴重程度: 禁忌併用
Atomoxetine and Selegiline transdermal: contraindicated interaction.
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摘要
Combining atomoxetine with an MAO inhibitor such as transdermal selegiline can cause hypertensive crisis and serotonin-like reactions. Atomoxetine labeling contraindicates use with MAOIs.
用白話說明這項交互作用的意義
Atomoxetine and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
MAO inhibition reduces catecholamine breakdown while atomoxetine blocks norepinephrine reuptake, causing excess noradrenergic stimulation.
處置方式
Do not co-administer. Allow at least 14 days after stopping selegiline before starting atomoxetine, and at least 2 weeks after stopping atomoxetine before starting selegiline.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Atomoxetine 的其他交互作用
常見問題
Can I take Atomoxetine with Selegiline transdermal?
MediHelp rates the interaction as contraindicated. Atomoxetine and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining atomoxetine with an MAO inhibitor such as transdermal selegiline can cause hypertensive crisis and serotonin-like reactions. Atomoxetine labeling contraindicates use with MAOIs.
How serious is the interaction between Atomoxetine and Selegiline transdermal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Allow at least 14 days after stopping selegiline before starting atomoxetine, and at least 2 weeks after stopping atomoxetine before starting selegiline.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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