藥物交互作用
Benzphetamine + Tranylcypromine
嚴重程度: 禁忌併用
Benzphetamine and Tranylcypromine: contraindicated interaction.
最後更新
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摘要
Benzphetamine is a sympathomimetic anorectic that releases norepinephrine, and MAO inhibition prevents catecholamine breakdown. The combination can precipitate hypertensive crisis with severe headache, arrhythmia and intracranial hemorrhage.
用白話說明這項交互作用的意義
Benzphetamine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Increased release of norepinephrine combined with blocked MAO-mediated catecholamine degradation causes exaggerated pressor responses.
處置方式
Do not use during or within 14 days of stopping tranylcypromine. Choose a non-sympathomimetic weight management approach.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Tranylcypromine 的其他交互作用
常見問題
Can I take Benzphetamine with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Benzphetamine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Benzphetamine is a sympathomimetic anorectic that releases norepinephrine, and MAO inhibition prevents catecholamine breakdown. The combination can precipitate hypertensive crisis with severe headache, arrhythmia and intracranial hemorrhage.
How serious is the interaction between Benzphetamine and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use during or within 14 days of stopping tranylcypromine. Choose a non-sympathomimetic weight management approach.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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