藥物交互作用
Buprenorphine + Olanzapine / samidorphan
嚴重程度: 禁忌併用
Buprenorphine and Olanzapine / samidorphan: contraindicated interaction.
最後更新
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摘要
Samidorphan blocks opioid receptors, reducing buprenorphine's effect and potentially precipitating withdrawal in opioid-dependent patients. This is a labeled contraindication in patients using opioids.
用白話說明這項交互作用的意義
Buprenorphine and Olanzapine / samidorphan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Samidorphan is a mu-opioid receptor antagonist that opposes buprenorphine's effects.
處置方式
Do not combine, and observe the labeled opioid-free interval before starting. Use a different antipsychotic for patients on buprenorphine maintenance.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Buprenorphine 的其他交互作用
常見問題
Can I take Buprenorphine with Olanzapine / samidorphan?
MediHelp rates the interaction as contraindicated. Buprenorphine and Olanzapine / samidorphan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Samidorphan blocks opioid receptors, reducing buprenorphine's effect and potentially precipitating withdrawal in opioid-dependent patients. This is a labeled contraindication in patients using opioids.
How serious is the interaction between Buprenorphine and Olanzapine / samidorphan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine, and observe the labeled opioid-free interval before starting. Use a different antipsychotic for patients on buprenorphine maintenance.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Phenelzine. The full list is on the Buprenorphine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
