藥物交互作用
Buprenorphine buccal + Orphenadrin
嚴重程度: 嚴重
Buprenorphine buccal and Orphenadrin: major interaction.
最後更新
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摘要
Combining a sedating muscle relaxant with an opioid can cause profound sedation and respiratory depression. Orphenadrine also adds anticholinergic effects such as constipation and urinary retention.
用白話說明這項交互作用的意義
Buprenorphine buccal and Orphenadrin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive CNS and respiratory depression, plus additive antimuscarinic effects.
處置方式
Avoid the combination if possible, otherwise use the lowest doses for the shortest duration. Monitor respiratory rate and sedation and advise against driving.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Orphenadrin 的其他交互作用
常見問題
Can I take Buprenorphine buccal with Orphenadrin?
MediHelp rates the interaction as major. Buprenorphine buccal and Orphenadrin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a sedating muscle relaxant with an opioid can cause profound sedation and respiratory depression. Orphenadrine also adds anticholinergic effects such as constipation and urinary retention.
How serious is the interaction between Buprenorphine buccal and Orphenadrin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, otherwise use the lowest doses for the shortest duration. Monitor respiratory rate and sedation and advise against driving.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
