藥物交互作用
Butabarbital + Ranolazine
嚴重程度: 禁忌併用
Butabarbital and Ranolazine: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Barbiturates induce CYP3A4 and can substantially lower ranolazine concentrations, causing loss of antianginal efficacy. Ranolazine labeling contraindicates use with CYP3A inducers.
用白話說明這項交互作用的意義
Butabarbital and Ranolazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Induction of CYP3A4 increases ranolazine metabolism.
處置方式
Do not use together; choose a non-inducing sedative or another antianginal. If an inducer is stopped, expect ranolazine exposure to recover over weeks.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Ranolazine 的其他交互作用
常見問題
Can I take Butabarbital with Ranolazine?
MediHelp rates the interaction as contraindicated. Butabarbital and Ranolazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Barbiturates induce CYP3A4 and can substantially lower ranolazine concentrations, causing loss of antianginal efficacy. Ranolazine labeling contraindicates use with CYP3A inducers.
How serious is the interaction between Butabarbital and Ranolazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose a non-inducing sedative or another antianginal. If an inducer is stopped, expect ranolazine exposure to recover over weeks.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
