藥物交互作用
Canagliflozin-metformin + Dichlorphenamide
嚴重程度: 嚴重
Canagliflozin-metformin and Dichlorphenamide: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Dichlorphenamide is a carbonic anhydrase inhibitor that causes hyperchloremic metabolic acidosis. Metformin carries a risk of lactic acidosis, and the acidosis from dichlorphenamide may increase this risk. Canagliflozin may also contribute to ketoacidosis in rare cases.
用白話說明這項交互作用的意義
Canagliflozin-metformin and Dichlorphenamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Canagliflozin-metformin belongs to Endocrine; Dichlorphenamide belongs to Miscellaneous.
為什麼會發生
Additive acidosis from carbonic anhydrase inhibition and impaired lactate clearance or increased lactate with metformin.
處置方式
Monitor serum bicarbonate and acid-base status at baseline and periodically, and avoid the combination if renal function is reduced. Stop or reconsider metformin if acidosis develops.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Canagliflozin-metformin 的其他交互作用
Dichlorphenamide 的其他交互作用
常見問題
Can I take Canagliflozin-metformin with Dichlorphenamide?
MediHelp rates the interaction as major. Canagliflozin-metformin and Dichlorphenamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dichlorphenamide is a carbonic anhydrase inhibitor that causes hyperchloremic metabolic acidosis. Metformin carries a risk of lactic acidosis, and the acidosis from dichlorphenamide may increase this risk. Canagliflozin may also contribute to ketoacidosis in rare cases.
How serious is the interaction between Canagliflozin-metformin and Dichlorphenamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum bicarbonate and acid-base status at baseline and periodically, and avoid the combination if renal function is reduced. Stop or reconsider metformin if acidosis develops.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
