藥物交互作用
Captopril-hydrochlorothiazide + Sacubitril / valsartan
嚴重程度: 禁忌併用
Captopril-hydrochlorothiazide and Sacubitril / valsartan: contraindicated interaction.
最後更新
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摘要
Neprilysin inhibition by sacubitril together with ACE inhibition impairs bradykinin breakdown and substantially raises the risk of angioedema, which can be life-threatening. Additional valsartan effects add to hypotension, hyperkalemia and renal risks.
用白話說明這項交互作用的意義
Captopril-hydrochlorothiazide and Sacubitril / valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Concurrent inhibition of neprilysin and ACE reduces bradykinin degradation, causing excess bradykinin-mediated angioedema.
處置方式
Never give together; allow at least 36 hours between the last ACE inhibitor dose and the first sacubitril/valsartan dose, and vice versa.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Captopril-hydrochlorothiazide 的其他交互作用
常見問題
Can I take Captopril-hydrochlorothiazide with Sacubitril / valsartan?
MediHelp rates the interaction as contraindicated. Captopril-hydrochlorothiazide and Sacubitril / valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Neprilysin inhibition by sacubitril together with ACE inhibition impairs bradykinin breakdown and substantially raises the risk of angioedema, which can be life-threatening. Additional valsartan effects add to hypotension, hyperkalemia and renal risks.
How serious is the interaction between Captopril-hydrochlorothiazide and Sacubitril / valsartan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Never give together; allow at least 36 hours between the last ACE inhibitor dose and the first sacubitril/valsartan dose, and vice versa.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Aceclofenac. The full list is on the Captopril-hydrochlorothiazide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
