藥物交互作用
Clemastine + Diamorphine
嚴重程度: 嚴重
Clemastine and Diamorphine: major interaction.
最後更新
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摘要
Diamorphine (heroin) is a potent opioid, and a sedating antihistamine adds to sedation and impaired alertness. Respiratory depression and profound sedation are possible, particularly at higher doses.
用白話說明這項交互作用的意義
Clemastine and Diamorphine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive CNS and respiratory depression from the opioid agonist and the sedating H1 antihistamine.
處置方式
Use the lowest effective doses and monitor sedation and respiratory rate. Prefer a non-sedating antihistamine when one is needed.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Clemastine 的其他交互作用
常見問題
Can I take Clemastine with Diamorphine?
MediHelp rates the interaction as major. Clemastine and Diamorphine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Diamorphine (heroin) is a potent opioid, and a sedating antihistamine adds to sedation and impaired alertness. Respiratory depression and profound sedation are possible, particularly at higher doses.
How serious is the interaction between Clemastine and Diamorphine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and respiratory rate. Prefer a non-sedating antihistamine when one is needed.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
