藥物交互作用
Clozapine + Tolterodine
嚴重程度: 嚴重
Clozapine and Tolterodine: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Clozapine has strong antimuscarinic activity, and combining it with tolterodine raises the risk of severe constipation, paralytic ileus, urinary retention, tachycardia and delirium. Clozapine-related gastrointestinal hypomotility can be dangerous.
用白話說明這項交互作用的意義
Clozapine and Tolterodine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clozapine belongs to Central Nervous System; Tolterodine belongs to Genitourinary.
為什麼會發生
Additive antimuscarinic pharmacodynamic effects.
處置方式
Avoid the combination if possible, or monitor bowel function closely and treat constipation early. Consider non-anticholinergic options for overactive bladder, such as a beta-3 agonist.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Tolterodine 的其他交互作用
Clozapine 的其他交互作用
常見問題
Can I take Clozapine with Tolterodine?
MediHelp rates the interaction as major. Clozapine and Tolterodine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clozapine has strong antimuscarinic activity, and combining it with tolterodine raises the risk of severe constipation, paralytic ileus, urinary retention, tachycardia and delirium. Clozapine-related gastrointestinal hypomotility can be dangerous.
How serious is the interaction between Clozapine and Tolterodine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, or monitor bowel function closely and treat constipation early. Consider non-anticholinergic options for overactive bladder, such as a beta-3 agonist.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Cobicistat, Dronedarone. The full list is on the Tolterodine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
