藥物交互作用
Desvenlafaxine + Rasagiline
嚴重程度: 禁忌併用
Desvenlafaxine and Rasagiline: contraindicated interaction.
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摘要
Rasagiline inhibits monoamine oxidase and so reduces serotonin breakdown, while desvenlafaxine blocks serotonin and norepinephrine reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal.
用白話說明這項交互作用的意義
Desvenlafaxine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Desvenlafaxine belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.
為什麼會發生
Additive serotonergic activity: irreversible MAO-B inhibition (selectivity is lost at higher doses) plus monoamine reuptake inhibition
處置方式
Do not combine; allow at least 14 days after stopping the rasagiline before starting desvenlafaxine, and at least 14 days after stopping desvenlafaxine before starting the rasagiline.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Desvenlafaxine 的其他交互作用
Rasagiline 的其他交互作用
常見問題
Can I take Desvenlafaxine with Rasagiline?
MediHelp rates the interaction as contraindicated. Desvenlafaxine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rasagiline inhibits monoamine oxidase and so reduces serotonin breakdown, while desvenlafaxine blocks serotonin and norepinephrine reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal.
How serious is the interaction between Desvenlafaxine and Rasagiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; allow at least 14 days after stopping the rasagiline before starting desvenlafaxine, and at least 14 days after stopping desvenlafaxine before starting the rasagiline.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Desvenlafaxine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
