藥物交互作用
Diatrizoate meglumine / diatrizoate + Glyburide-metformin
嚴重程度: 嚴重
Diatrizoate meglumine / diatrizoate and Glyburide-metformin: major interaction.
最後更新
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摘要
Iodinated contrast can cause acute kidney injury, which reduces metformin clearance and may lead to metformin accumulation and lactic acidosis. The risk is greatest with impaired renal function or intra-arterial administration.
用白話說明這項交互作用的意義
Diatrizoate meglumine / diatrizoate and Glyburide-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Contrast-induced decline in renal function reduces metformin elimination and raises the risk of lactic acidosis.
處置方式
Hold metformin at the time of or before contrast in patients with eGFR below 30, liver disease or intra-arterial studies. Restart after 48 hours only once renal function is confirmed stable.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Glyburide-metformin 的其他交互作用
常見問題
Can I take Diatrizoate meglumine / diatrizoate with Glyburide-metformin?
MediHelp rates the interaction as major. Diatrizoate meglumine / diatrizoate and Glyburide-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Iodinated contrast can cause acute kidney injury, which reduces metformin clearance and may lead to metformin accumulation and lactic acidosis. The risk is greatest with impaired renal function or intra-arterial administration.
How serious is the interaction between Diatrizoate meglumine / diatrizoate and Glyburide-metformin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold metformin at the time of or before contrast in patients with eGFR below 30, liver disease or intra-arterial studies. Restart after 48 hours only once renal function is confirmed stable.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
