藥物交互作用
Diazoxide + Metformin-sitagliptin
嚴重程度: 嚴重
Diazoxide and Metformin-sitagliptin: major interaction.
最後更新
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摘要
Oral diazoxide causes hyperglycemia by suppressing insulin secretion and directly opposes antidiabetic drugs. Glycemic control may deteriorate markedly.
用白話說明這項交互作用的意義
Diazoxide and Metformin-sitagliptin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diazoxide belongs to Miscellaneous; Metformin-sitagliptin belongs to Endocrine.
為什麼會發生
Diazoxide opens pancreatic beta-cell ATP-sensitive potassium channels, inhibiting insulin release and producing pharmacodynamic antagonism.
處置方式
Monitor blood glucose frequently and increase antidiabetic therapy if needed; avoid the combination if control cannot be maintained.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Metformin-sitagliptin 的其他交互作用
Diazoxide 的其他交互作用
常見問題
Can I take Diazoxide with Metformin-sitagliptin?
MediHelp rates the interaction as major. Diazoxide and Metformin-sitagliptin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oral diazoxide causes hyperglycemia by suppressing insulin secretion and directly opposes antidiabetic drugs. Glycemic control may deteriorate markedly.
How serious is the interaction between Diazoxide and Metformin-sitagliptin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently and increase antidiabetic therapy if needed; avoid the combination if control cannot be maintained.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
