藥物交互作用
Enalapril + Protein a column
嚴重程度: 禁忌併用
Enalapril and Protein a column: contraindicated interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Patients taking ACE inhibitors who undergo immunoadsorption with a protein A column have had severe anaphylactoid reactions with flushing, hypotension, and dyspnea. Bradykinin accumulation is thought to be responsible.
用白話說明這項交互作用的意義
Enalapril and Protein a column are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
ACE inhibition reduces bradykinin breakdown, and column-activated bradykinin generation leads to anaphylactoid reactions.
處置方式
Stop enalapril well before the procedure (labeling suggests about 72 hours) and use an alternative antihypertensive. Consider a different apheresis membrane if the ACE inhibitor cannot be stopped.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Enalapril 的其他交互作用
常見問題
Can I take Enalapril with Protein a column?
MediHelp rates the interaction as contraindicated. Enalapril and Protein a column are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Patients taking ACE inhibitors who undergo immunoadsorption with a protein A column have had severe anaphylactoid reactions with flushing, hypotension, and dyspnea. Bradykinin accumulation is thought to be responsible.
How serious is the interaction between Enalapril and Protein a column?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop enalapril well before the procedure (labeling suggests about 72 hours) and use an alternative antihypertensive. Consider a different apheresis membrane if the ACE inhibitor cannot be stopped.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Enalapril page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
