藥物交互作用
Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir
嚴重程度: 禁忌併用
Ethinyl estradiol-drospirenone and Ombitasvir / paritaprevir / ritonavir and dasabuvir: contraindicated interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Coadministration of ethinyl estradiol-containing products with this HCV regimen has produced marked ALT elevations in clinical trials. The risk of liver injury makes the combination unsuitable. Drospirenone also carries a hyperkalemia concern with strong CYP3A inhibitors such as ritonavir.
用白話說明這項交互作用的意義
Ethinyl estradiol-drospirenone and Ombitasvir / paritaprevir / ritonavir and dasabuvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
The mechanism of the ALT elevation is not established; ritonavir also inhibits CYP3A4 and may raise drospirenone exposure.
處置方式
Avoid ethinyl estradiol-containing contraceptives before and during this regimen. Switch to a progestin-only or non-hormonal method and restart estrogen only after the regimen has been completed, as advised in the labeling.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ 會員專屬
解鎖完整頁面
建立帳號並開始 Pro+ 試用，即可解鎖 Ethinyl estradiol-drospirenone 與 Ombitasvir / paritaprevir / ritonavir and dasabuvir 的完整臨床處置建議、補充說明、證據詳情及整張處方的交互作用檢查工具。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
在網頁版免費試用 Pro+ 14 天，無需信用卡。
Ethinyl estradiol-drospirenone 的其他交互作用
- Ethinyl estradiol-drospirenone + Fezolinetant 禁忌併用
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir 禁忌併用
- Ethinyl estradiol-drospirenone + Tranexamic acid 禁忌併用
- Aminocaproic acid + Ethinyl estradiol-drospirenone 嚴重
- Amobarbital + Ethinyl estradiol-drospirenone 嚴重
- Anastrozole + Ethinyl estradiol-drospirenone 嚴重
常見問題
Can I take Ethinyl estradiol-drospirenone with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as contraindicated. Ethinyl estradiol-drospirenone and Ombitasvir / paritaprevir / ritonavir and dasabuvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Coadministration of ethinyl estradiol-containing products with this HCV regimen has produced marked ALT elevations in clinical trials. The risk of liver injury makes the combination unsuitable. Drospirenone also carries a hyperkalemia concern with strong CYP3A inhibitors such as ritonavir.
How serious is the interaction between Ethinyl estradiol-drospirenone and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ethinyl estradiol-containing contraceptives before and during this regimen. Switch to a progestin-only or non-hormonal method and restart estrogen only after the regimen has been completed, as advised in the labeling.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Tranexamic acid. The full list is on the Ethinyl estradiol-drospirenone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
