藥物交互作用
Ganaxolone + Phenytoin
嚴重程度: 嚴重
Ganaxolone and Phenytoin: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Phenytoin can lower ganaxolone concentrations through CYP3A4 induction, potentially reducing seizure control in CDKL5 deficiency disorder. Ganaxolone labeling advises avoiding moderate and strong CYP3A4 inducers.
用白話說明這項交互作用的意義
Ganaxolone and Phenytoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ganaxolone belongs to Central Nervous System; Phenytoin belongs to Central Nervous System.
為什麼會發生
Phenytoin induces CYP3A4, accelerating ganaxolone metabolism.
處置方式
Avoid the combination where possible. If unavoidable, consider increasing the ganaxolone dose within the maximum for the patient's weight and monitor seizure frequency and sedation.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Phenytoin 的其他交互作用
Ganaxolone 的其他交互作用
常見問題
Can I take Ganaxolone with Phenytoin?
MediHelp rates the interaction as major. Ganaxolone and Phenytoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenytoin can lower ganaxolone concentrations through CYP3A4 induction, potentially reducing seizure control in CDKL5 deficiency disorder. Ganaxolone labeling advises avoiding moderate and strong CYP3A4 inducers.
How serious is the interaction between Ganaxolone and Phenytoin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If unavoidable, consider increasing the ganaxolone dose within the maximum for the patient's weight and monitor seizure frequency and sedation.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
