藥物交互作用
Glipizide + Sulfamethoxazole
嚴重程度: 嚴重
Glipizide and Sulfamethoxazole: major interaction.
最後更新
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摘要
Sulfamethoxazole, usually given with trimethoprim, has been linked to hypoglycemia in patients taking sulfonylureas. Cases can be severe, especially in older patients or those with kidney disease.
用白話說明這項交互作用的意義
Glipizide and Sulfamethoxazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Inhibition of CYP2C9 and displacement from protein binding raise free glipizide; trimethoprim may add to hypoglycemia.
處置方式
Monitor blood glucose closely and consider reducing the glipizide dose, or use an alternative antibiotic in high-risk patients.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Glipizide 的其他交互作用
常見問題
Can I take Glipizide with Sulfamethoxazole?
MediHelp rates the interaction as major. Glipizide and Sulfamethoxazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sulfamethoxazole, usually given with trimethoprim, has been linked to hypoglycemia in patients taking sulfonylureas. Cases can be severe, especially in older patients or those with kidney disease.
How serious is the interaction between Glipizide and Sulfamethoxazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and consider reducing the glipizide dose, or use an alternative antibiotic in high-risk patients.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
