藥物交互作用
Lefamulin + Pimavanserin
嚴重程度: 禁忌併用
Lefamulin and Pimavanserin: contraindicated interaction.
最後更新
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摘要
Lefamulin inhibits CYP3A4 and raises exposure to CYP3A substrates, and it also prolongs the QT interval. Pimavanserin is a CYP3A4 substrate that itself prolongs QT, so the combination increases the risk of torsades de pointes. Lefamulin labeling contraindicates the oral form with QT-prolonging CYP3A substrates.
用白話說明這項交互作用的意義
Lefamulin and Pimavanserin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lefamulin belongs to Anti Bacterial; Pimavanserin belongs to Central Nervous System.
為什麼會發生
CYP3A4 inhibition raises pimavanserin exposure, and both drugs have additive QT-prolonging effects.
處置方式
Avoid the combination and choose an antibiotic without QT or CYP3A4 effects. If unavoidable, ECG and electrolyte monitoring are needed with pimavanserin dose reduction.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pimavanserin 的其他交互作用
Lefamulin 的其他交互作用
常見問題
Can I take Lefamulin with Pimavanserin?
MediHelp rates the interaction as contraindicated. Lefamulin and Pimavanserin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lefamulin inhibits CYP3A4 and raises exposure to CYP3A substrates, and it also prolongs the QT interval. Pimavanserin is a CYP3A4 substrate that itself prolongs QT, so the combination increases the risk of torsades de pointes. Lefamulin labeling contraindicates the oral form with QT-prolonging CYP3A substrates.
How serious is the interaction between Lefamulin and Pimavanserin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antibiotic without QT or CYP3A4 effects. If unavoidable, ECG and electrolyte monitoring are needed with pimavanserin dose reduction.
What other medicines interact with Pimavanserin?
MediHelp also lists interactions of Pimavanserin with, for example, Pimozide, Vandetanib, Adagrasib. The full list is on the Pimavanserin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
